Sumo 2+3 [3H12] est un gène codé par le symbole SUMO3. Il est également connu sous le nom de: Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO3; SMT3A; SMT3H1. Sumo 2+3 [3H12] a une masse de 11.64kDa et une longueur d'acide aminé de 103.
Nous proposons 10 des anticorps contre Sumo 2+3 [3H12], élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Résumé Entrez
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described.
Spécificité tissulaire
Expressed predominantly in liver.
Similitudes de séquence
Belongs to the ubiquitin family. SUMO subfamily.
Modification post-traductionnelle
Polymeric chains can be formed through Lys-11 cross-linking.
Localisation cellulaire
Cytoplasm. Nucleus. Nucleus > PML body.
